While many of The Blood operate independently, nearly all of them are at least watched by one of the major factions. These groups are composed of humans and Blood, working together with varying degrees of willingness. The factions generally look for other members of the Blood to recruit. Each of the factions has their own goals and ideas about what the Blood are, and what should be done with them. These purposes are often in conflict.

• Black Blood
• The Order
• The Grail Society
• Tarot Corporation
• The Double Helix Club
• The Independants

Each faction provides its members a choice of one faction bonus.